Antibacterial

The library has been designed with similarity search that was carried out against reference set of compounds that possess activity in treatment of pathogenic bacteria. The information about the activity has been gathered from the most reliable compound activity databases (ChEMBL, BindingDB) and PubChem (in case when compounds were mentioned as potent pro-drugs in specialized literature). The final library included compounds within Tanimoto index range 0.8 - 0.85 chosen based on activity data and number of compounds in the reference subsets.

The reference set included inhibitors of the following pathogenic bacteria:
● Pseudomonas aeruginosa
● Neisseria meningitides
● Klebiela pneumonia
● Esherichia coli
● Acinetobacter baumannii